Welcome to Dr. Christophe QUENTIN's Blog

It began when a 70-year-old patient came to me at my family practice for knee osteoarthritis.
I was discussing with him a plan for a prosthesis, so I sent him to an orthopedic surgeon for advice.

Some weeks later, the patient came back smiling, without having needed any surgery.
He had just been given PRP therapy, which consists of platelet-enriched plasma injections.

Blood is taken from the patient and centrifuged to obtain the fraction containing plasma and platelets.
This is administered through a joint injection.
The biological phenomenon involved is that, once inside the knee, platelets release healing substances.

First, we find growth factors that boost neo-vascularisation to bring components needed to repair the altered part of the cartilage and help with toxic waste elimination.
Next, we have cytokines that modulate inflammation by decreasing white cell activity.
Lastly, we find membrane-derived microvesicles like exosomes, containing substances such as modulating RNA.

At first, I was skeptical about the impressive results my patient reported and wanted to be sure they were not simply due to a placebo effect.
I wanted to understand if there was something more substantial behind them. Relying on my training in evidence-based medicine, I turned to the scientific literature, exploring peer-reviewed journals and specialized databases in search of well-conducted randomized clinical trials with meaningful statistical evidence.

Although we still need some standardization in these explorations, I will share with you some knowledge treasures I have found in renowned scientific publications.