Clinical Significance
CAA density correlates with poor prognosis (HR=2.1, 95% CI 1.6-2.8)1. Exosomal transfer mediates 73% of tumor-adipocyte crosstalk2.
Cancer-Associated Adipocytes (CAA)
Mechanistic Features
| Feature | Impact | Reference |
|---|---|---|
| Lipid Metabolism | ↑FFA release (2.4x control) | PMID: 33577785 |
| EMT Induction | ↑Snail1 expression | Nat Cell Biol 2019 |
Exosomal Mediators
- miR-105 suppresses ZNF32 → ↑metastasis
- HSP90α activates PI3K/Akt (OR=3.4)