Structural Diversity
- Alternative splicing variants
- Post-translational modifications
- Tissue-specific expression patterns
Protein Isoforms in Exosomal Signaling
Key Isoform Functions
Disease Associations
- KRAS isoforms in pancreatic cancer
- APP isoforms in metabolic dementia
- GLUT4 variants in insulin resistance
Isoform Analysis Techniques
graph TB
A[Mass Spectrometry] --> B(Isoform Identification)
C[RNA-seq] --> D(Alternative Splicing Detection)
E[2D Gel Electrophoresis] --> F(Post-Translational Modifications)