Exosome Research Hub

Exploring the Role of Exosomes in Cancer, Inflammation and Metabolic Diseases

Current Challenges in Pancreatic Cancer Diagnosis

Early detection of pancreatic cancer remains one of the most significant challenges in oncology. The absence of specific symptoms in early stages and the deep anatomical location of the pancreas contribute to late diagnosis in many cases. Recent advances in biomarker research and diagnostic technologies are opening new possibilities for earlier and more accurate detection.

Traditional Serum Biomarkers

CA 19-9

Standard tumor marker for pancreatic cancer

Sensitivity: ~80%

Emerging Exosomal Markers

Exosomal miRNAs

Novel liquid biopsy approaches

Potential Accuracy: ~85%

Genetic Markers

KRAS Mutations

Early molecular detection

Specificity: ~90%

Metabolic Markers

Metabolomics Profile

Complex metabolic signatures

Accuracy: ~75%

Advanced Diagnostic Tools

Imaging Techniques

  • CT with contrast enhancement
  • MRI with specific protocols
  • Endoscopic ultrasound (EUS)
  • PET/CT for staging

Molecular Testing

  • Next-generation sequencing
  • Liquid biopsy analysis
  • Proteomics profiling
  • Circulating tumor DNA