Exosome Research Hub

Exploring the Role of Exosomes in Cancer, Inflammation and Metabolic Diseases

Heat Shock Proteins in Metabolic Pathologies

HSP70 in Metabolic Dysregulation

Obesity & Inflammation

  • Adipocyte HSP70 overexpression in obesity (DOI: 10.2337/db10-1578)
  • TLR4-mediated inflammation via extracellular HSP70
  • Exosomal HSP70 promotes macrophage M1 polarization

Pancreatic Cancer

  • Chaperones mutant KRAS in PDAC (DOI: 10.1158/0008-5472.CAN-14-0727)
  • Stabilizes oncogenic client proteins
  • Tumor-derived exosomal HSP70 inhibits DC maturation

HSP90 in Disease Progression

Diabetes Mechanisms

  • Regulates insulin receptor stability (DOI: 10.1172/JCI13505)
  • ER stress mitigation in β-cells
  • Exosomal HSP90α enhances insulin resistance

Cancer Therapeutics

  • Geldanamycin analogs target HSP90 in PDAC
  • Combination with gemcitabine (DOI: 10.1158/1078-0432.CCR-10-3375)
  • Exosomal HSP90 inhibition blocks metastasis

Clinical Landscape

Inhibitor Target Phase Disease Focus

Exosomal HSP Networks

Diagnostic Potential

  • Serum exosomal HSP90α as PDAC biomarker (DOI: 10.1038/s41392-020-00349-7)
  • HSP60-containing exosomes in diabetic nephropathy
  • Proteostasis signature analysis