Exosome Research Hub

Exploring the Role of Exosomes in Cancer, Inflammation and Metabolic Diseases

Interferon Signaling in Metabolic Pathology

Type I/II IFN Effects

Obesity Paradox

  • IFN-γ promotes adipose inflammation (DOI:10.1016/j.immuni.2014.03.005)
  • IFN-α impairs adipocyte differentiation
  • Exosomal IFN-λ in NAFLD progression

Cancer Immunology

  • IFN-γ-driven PD-L1 expression (DOI:10.1158/2326-6066.CIR-14-0162)
  • STING pathway activation defects
  • Exosomal IFNAR1 in resistance

Clinical Applications

Therapy Target Phase Outcome

Exosomal Crosstalk

Immune Modulation

  • IFN-γ-primed exosomes enhance CTL activity
  • Tumor-derived exosomal IFN-γ traps
  • STING agonist-loaded exosomes

Diagnostic Potential

  • Exosomal IFN signature in PDAC
  • IFN-stimulated gene products as biomarkers
  • Liquid biopsy for IFN pathway activity