Exosome Research Hub

Exploring the Role of Exosomes in Cancer, Inflammation and Metabolic Diseases

NASH & Fibrosis Mechanisms

Exosomal Biomarkers in Liver Disease

Key miRNAs

  • miR-122: Hepatocyte stress marker (AUC=0.91 for NASH detection)1
  • miR-34a: Fibrosis progression (Correlates with FIB-4 score, r=0.67)2
  • miR-192: Inflammation regulation (Targets ZEB2 in HSCs)

Pathways

  • TGF-β/SMAD3 signaling (PMID: 33577785)
  • LOXL2-mediated collagen crosslinking
  • HSC activation via exosomal PDGF-D

Therapeutic Targets

Target Mechanism Evidence
miR-34a antagomir Reduces collagen I/III expression Phase II (NCT04613324)
Galectin-3 inhibitor (Belapectin) Blocks macrophage recruitment Phase III (NCT04365868)
FXR agonist (Obeticholic acid) Modulates bile acid metabolism REGENERATE trial3

Key References

1. Cheung O, 2008 (Gastroenterology)
2. Lee J, 2021 (Journal of Hepatology)
3. Younossi ZM, 2019 (Lancet)