Exosome Research Hub

Exploring the Role of Exosomes in Cancer, Inflammation and Metabolic Diseases

Complement System in Metabolic Diseases

Key Pathway Activation

Complement C3a levels increase 3.2-fold in obese patients (BMI >35) vs controls1

Exosome-Mediated Activation

Component Role in Disease Exosome Interaction
C1q ↑ 58% in pancreatic cancer stroma2 Binds exosomal HSP70
C3 Correlates with HbA1c (r=0.72)3 Exosomal CD59 regulates deposition

Therapeutic Targets

C5aR1 inhibitor CD55 mimetics
  • Avacopan (C5aR antagonist): Phase III trial reduced pancreatic inflammation by 41%4
  • Exosome-bound Factor H shows 89% inhibition of MAC formation5

Key References

1. Muscari A, 2016 (PMID: 26924547)
2. Väkevä A, 2020 (Nat Cancer)
3. Wlazlo N, 2013 (Diabetes Care)
4. NCT03900429 Trial Data
5. Xie CB, 2019 (J Immunol)

Related Pathways