| miRNA | Disease Association | Function | Expression Pattern |
|---|---|---|---|
| miR-21 | Pancreatic Cancer, Inflammation | Promotes tumor growth and metastasis | Upregulated |
| miR-375 | Diabetes, β-cell function | Regulates insulin secretion | Downregulated in diabetes |
| miR-155 | Inflammation, Fibrosis | Modulates immune response | Upregulated |
| miR-200 | EMT, Metastasis | Controls epithelial phenotype | Variable |
Circular RNAs are unique RNA molecules that form a closed continuous loop. Their stable structure and tissue-specific expression patterns make them excellent biomarker candidates.
| circRNA | Target/Function | Disease Impact | Clinical Relevance |
|---|---|---|---|
| circ-LDLRAD3 | miR-137-3p sponge | Promotes tumor progression | Diagnostic marker |
| circ-IARS | Enhances tumor metastasis | Increases permeability | Prognostic indicator |
| circ-PDE8A | miR-338 regulation | Invasive progression | Survival predictor |
Long non-coding RNAs are RNA transcripts longer than 200 nucleotides that don't encode proteins. They play crucial roles in gene regulation and disease development.
| lncRNA | Mechanism | Disease Role | Clinical Significance |
|---|---|---|---|
| HOTAIR | Chromatin modification | Promotes metastasis | Poor prognosis marker |
| MALAT1 | Splicing regulation | Cell proliferation | Therapeutic target |
| H19 | miRNA regulation | Glucose metabolism | Diabetes biomarker |
| NEAT1 | Nuclear organization | Inflammation | Disease progression |