Exosome Research Hub

Exploring the Role of Exosomes in Cancer, Inflammation and Metabolic Diseases

mTOR Pathways in Metabolic Dysregulation

Obesity-Diabetes Nexus

mTORC1 in Adipogenesis

  • Regulates PPARγ-mediated lipid storage (DOI:10.1016/j.cmet.2015.12.003)
  • Leptin resistance via SOCS3 induction
  • Exosomal mTOR transfer to hepatocytes

Pancreatic Cancer Mechanisms

  • KRAS-mTOR crosstalk in PDAC (DOI:10.1158/2159-8290.CD-13-0619)
  • Autophagy addiction in nutrient-starved tumors
  • Exosomal mTORC1 in pre-metastatic niche

Therapeutic Landscape

Compound Target Trial Phase Cancer Type