Epigenetic Regulation in Metabolic Diseases
DNA Methylation Patterns
- Hypermethylation of PPARĪ³ in obesity
- Global hypomethylation in cancer
- Nutrition-sensitive methylation sites
graph LR
A[DNMTs] --> B(DNA Methylation)
B --> C(Gene Silencing)
Histone Modification Landscape
| Modification | Effect | Disease Link |
|---|---|---|
| H3K27ac | Enhancer activation | Pancreatic cancer |
| H4K20me3 | Heterochromatin | Metabolic memory |
Exosomal Epigenetic Transfer
- Transfer of DNMTs between cells
- miRNA-mediated chromatin remodeling
- Circulating nucleosome biomarkers